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M94A2715.TXT
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Document 2715
DOCN M94A2715
TI Comparative clinical evaluation of an anti-HIV 1 + 2 3.gen EIA with a
HIV antigen EIA in seroconversion phase.
DT 9412
AU Faatz E; Melchior W; Hess G; Jilek F; Babiel R; Boehringer Mannheim
GmbH, Penzberg, Germany.
SO Int Conf AIDS. 1994 Aug 7-12;10(1):241 (abstract no. PB0395). Unique
Identifier : AIDSLINE ICA10/94369860
AB OBJECTIVE: Since the necessity of HIV antigen immunoassays for the
detection of early seroconversion in blood banks is still discussed
controversially, we did a comparative study of two HIV-antigen
immunoassays and two anti-HIV immunoassays. The anti-HIV immunoassays
were chosen to be those using a double antigen or bridging test concept,
for this type of test concept theoretically is able to detect all immune
globulin classes including IgM and is therefore considered to be the
most sensitive type of antibody immunoassay in seroconversion. METHODS:
The Boehringer Mannheim Enzymun-Test HIVAg, one competitor HIVAg EIA,
the Boehringer Mannheim Enzymun-Test anti-HIV 3.generation and one
competitor anti-HIV 3.generation EIA were used to evaluate 8
seroconversion panels, the Boston Biomedica HIV antigen mixed titer
panel and anti-HIV Low Titer Panel 104 and several other critical
samples from different sources. RESULTS: The detection of positive
samples is very comparable between the Enzymun-Test HIVAg and the
competitor HIVAg EIA and the Boehringer Mannheim Enzymun-Test anti-HIV
3.generation and the competitor anti-HIV 3.generation EIA respectively.
With seroconversion panels I and L the first available bleed is positive
in all four immunoassays. Since no earlier negative bleed is available
with these panels no decision can be made which method would have
detected these seroconversions earlier. The seroconversion panels E, P,
Q, R, S, and NYBC Panel A are detected one to three bleeds earlier by
the antigen assays, which is 7 to 51 days earlier than detection by
anti-HIV 3.generation assays. DISCUSSION: The usefulness of a HIVAg
screening assay for blood transfusion survey in addition to established
anti-HIV screening assays will be discussed.
DE Blood Banks Comparative Study Human HIV Antigens/*BLOOD HIV
Seropositivity/*DIAGNOSIS/IMMUNOLOGY HIV-1/*IMMUNOLOGY
HIV-2/*IMMUNOLOGY *Immunoenzyme Techniques Predictive Value of Tests
MEETING ABSTRACT
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).